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This information was also reported by another group in 2005[38]

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Nephron Physiol (2014) 128(1-2):17

Although this is consistent and mechanistically validated across different preclinical models, as reviewed in the Preclinical and clinical applications of NAD + -modulating interventions for mitochondrial homeostasis and health benefits section, the correspondence between NAD + changes and mitochondrial or metabolic alterations is more complex in human studies