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Certain genetic variants in appetite-regulating pathwayssuch as FTO rs9939609, MC4R rs17782313, and GLP1R rs6923761directly influence how your body responds to hunger signals and metabolic adaptation

Although not directly traced here, NSC fatessuch as immunomodulation, trophic support, or differentiationare well-documented elsewhere [48,49,50]

Patients assigned to tirzepatide showed a 20.9% BW loss after 36 weeks with an additional 5.5% reduction after 52 weeks, while those who switched to placebo experienced a 14% weight regain, confirming the findings from STEP 4 supporting the chronicity of obesity and the need for continuous treatment

doi: 10.3389/fonc.2023.1234887 204 LiWLiCLiuTSongYChenPLiuLet al

Ghusn W et al