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Modulation of sleep architecture, including delta-wave sleep patterns (preclinical models) Influence on GABAergic neurotransmission and neuronal excitability Interaction with opioid receptor signaling pathways in experimental settings Regulation of hypothalamicpituitaryadrenal (HPA) axis activity and cortisol response Potential effects on circadian rhythm-related gene expression and biological timing Observed stress-adaptive responses in animal models Investigated neuroprotective effects under cellular stress conditions Current evidence remains limited, and further well-controlled clinical studies are required to establish long-term efficacy and safety in humans

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2025;145:908-918.e6