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Most GLP-1 method failures trace back to a small set of root causes: non-specific adsorption on metal surfaces producing tailing and lost sensitivity, gradients too steep to resolve critical pairs, insufficient column efficiency for trace impurities, and sample diluents that destabilize the peptide before it reaches the column

doi: 10.1016/j.bbrc.2019.09.032 74 ConradMPronethB

Other reported musculoskeletal side effects include myalgias, muscle weakness, and muscle spasms