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Thyroid-related risks, including C-cell hyperplasia observed in rodents, underline theoretical concerns, although human evidence remains limited[12]

however, studies have only identified this risk in animals

In summary, the background context has three components: (a) GLP-1 medications are clinically important but costly and administratively challenging

The graphical abstract and the schemes in the figures were using BioRender

Preclinical data show this additive-to-synergistic interaction: each pathway potentiates the other's pituitary response, producing larger GH pulses without proportionally increasing side effects