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SFN is a sulfur-containing isothiocyanate that is mainly derived from the family of Brassicaceae flowering plants, also known as Cruciferae ( Brassica oleracea , which includes some widespread edible vegetables such as broccoli, cabbage, brussels sprouts, cauliflower, and kale ( Figure 1B ) ( Figure 1 The natural production of SFN occurs principally via a chemical reaction between glucoraphanin and plant thioglucosidases (myrosinases) after tissue damage or, if myrosinases were denatured via cooking before freezing, the reaction will occur between glucoraphanin and microbial thioglucosidases in the colon ( Figure 1C demonstrates the mechanism of the hydrolysis of glucoraphanin by myrosinase and the subsequent production of its biologically active metabolite, SFN

Ongoing low-dose exposure prevents full immune resolution, lowers physiological resilience, and increases vulnerability to secondary stressors

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Trends Biotechnol 26(4):210217 Rosca VE et al (2011) Anti-angiogenic peptides for cancer therapeutics

Increased caspase-3 immunoreactivity of erythrocytes in STZ diabetic rats