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MIF null mice are entirely resistant to the detrimental effects of OVX, implying that MIF acts as a key downstream mediator of both the detrimental effects of estrogen deficiency and the beneficial effects of estrogen replacement on skin wound healing [57, 175, 182]

The GSH protective effect on cancer cells might indeed contrast anticancer drugs efficacy while not offering a solution to patients toxicities

variable absorption due to first-pass metabolism

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