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Claims that B12 shots enhance energy, improve mood, or facilitate weight loss in people without deficiency are not supported by high-quality clinical trials

They support general mitochondrial function by increasing a crucial coenzyme but do not directly address cardiolipin damage or membrane structure

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Effects of combined aerobic and resistance training on glycemic control, blood pressure, inflammation, cardiorespiratory fitness and quality of life in patients with type 2 diabetes and overweight/obesity: a systematic review and meta-analysis

Furthermore, it has been observed that, in HG-induced rat retinal endothelial cells and STZ-induced SD rat models, it was found that PKC /Drp1 mediated mitochondrial fission increased and HK-II-PINK1 mediated mitophagy decreased