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The mechanisms of action are fundamentally different: GLP-1 agonists are synthetic or modified peptides designed to mimic incretin hormones and directly stimulate specific cellular receptors, while allulose is a simple sugar that undergoes passive absorption and excretion

Chen G, Xu S, Renko K, Derwahl M

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Two percent provides meaningful activity without overwhelming the sensitive tissue around the eyes

Nonetheless, aberrant expression of SERT in both the intestine and liver contributes to lipid accumulation and inflammation in the liver