20 , e1004188
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However, over the past decade, landmark cardiovascular outcomes trials of sodium-glucose cotransporter type 2 inhibitors (SGLT2is) and glucagon-like peptide-1 receptor agonists (GLP-1RAs) have transformed this paradigm [5,6,7,8,9,10,11]
These medications should also be used cautiously in individuals with certain medical conditions, such as epilepsy, untreated hypothyroidism, obesity, hyperglycemia, or elevated levels of plasma fatty acids, as these conditions may increase the risk of adverse effects or alter the drugs response
This effect is well documented: in a study titled Bismuth subsalicylate markedly decreases hydrogen sulfide release in the human colon (Suarez, Furne, Springfield and Levitt, Gastroenterology , 1998), 10 healthy subjects who took bismuth subsalicylate (524 mg four times daily) showed a greater than 95% reduction in fecal hydrogen sulfide release which is why this remedy can work so reliably against the odor itself
