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[25] NAD+ deficient cells from WS patient samples and WS animal models displayed poor mitophagy (selective degradation of defective mitochondria)

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To achieve this, we compared data from G49-treated mice in the presence of either or both antagonists to their respective control groups (antagonists in the absence of G49)

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GLP-1 agonists are medications like semaglutide and tirzepatide (Ozempic, Wegovy, Mounjaro, Zepbound)