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Until then, scientists thought drug use and drug-specific cues triggered an excessive surge of dopamine, the so-called pleasure hormone, which drives craving, addiction and relapse

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Compensation for blood pressure reduction and stimulation of the sinus node and sympathetic nervous system appear to speed up the pulse

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Clarifying these factors is essential for future trial design, the optimization of inclusion criteria, and the identification of the clinical phenotypes and healthcare settings most likely to benefit from GCSF therapy