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Reactive Metabolites Detection XenoScreen GSH-EE (Tube type) is useful for identification of candidate drug compounds that produce reactive metabolites

It is a metabolite of the glutathione cycle and can be converted to glutamate by 5-hydroxyprolinase

More serious concerns include pancreatitis and a warning about medullary thyroid carcinoma, which limits use in people with certain genetic risks

Some of these adverse reactions may have long-term implications even after stopping the drug

NAT1 has also been detected in cancer cells, in which it may not only play a role in the development of cancers through enhanced mutagenesis but may also contribute to the resistance of some cancers to cytotoxic drugs (Adam et al., 2003)