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This effect was previously documented in the DCCT and UKPDS trials and occurs regardless of the treatment method used (insulin, oral agents, or GLP-1 medications), reflecting changes in retinal blood flow and vascular permeability during metabolic adjustment

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Microdosing refers to the practice of consuming a low dose of GLP-1 drugs (off-label) instead of the standard therapeutic dose to achieve mild weight loss or appetite benefits with fewer side effects at a lower cost