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These results indicate a dose-dependent response where the body adjusts gradually over a structured titration schedule, typically expressed in mg per week

In terms of the renal effects as these agents play a role in the reduction of glucose and increased reabsorption, it leads to the delivery of sodium to the macula densa and the tubuloglomerular feedback mechanisms activation

After incubation for 15 min in a 32 C water bath and 1 h at ambient temperature, the slices were loaded with Fura-2-AM (4 mM

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