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While the weight-loss data for semaglutide are encouraging, to really get the cardiologists excited about prevention and weight loss, especially addressing weight loss in the context of a cardiovascular visit, what is needed are CV outcomes trials that show meaningful outcomes differences, Neeland said in an interview

Its active compound, silybin, helps protect liver cell membranes and may even stimulate the production of new liver tissue

These variations significantly influence the role of GLP-1 in regulating islet function and glucose homeostasis.131 Research indicates that the expression level of GLP-1R on -cells is relatively low.131 Although GLP-1Rs are present, they are limited in number, making the direct inhibitory effect of GLP-1 on -cells relatively weak.247 The primary action often occurs through indirect mechanisms, such as insulin and somatostatin.244 Conversely, the expression level of GLP-1R on -cells is relatively high.248 GLP-1 can effectively bind to receptors on -cells, stimulating the secretion of somatostatin.248 As a broad-spectrum inhibitory hormone, somatostatin can effectively inhibit glucagon secretion from -cells and insulin secretion from -cells.249,250 Relevant studies suggest that the expression of GLP-1R on -cells is crucial for GLP-1s regulation of somatostatin secretion and the overall inhibitory effect on glucagon.248,251,252 This mechanism is particularly evident in the use of GLP-1-based drugs, such as GLP-1RAs, in the treatment of T2DM

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Oprah Winfrey is hosting a sit-down conversation around the impact of prescription weight loss medications in the ABC primetime event, "An Oprah Special: Shame, Blame and the Weight Loss Revolution." Airing Monday, March 18 at 8 p.m