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Previous studies have reported that RGSH can inhibit oxidative stress and thus alleviate liver damage (27), and improve renal function in patients by reducing the serum creatinine levels (28)

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Additionally, dysregulation of glycogen synthase kinase-3 beta (GSK-3) and reduced brain-derived neurotrophic factor (BDNF) levels further compromise neuronal survival and synaptic function 9,10,11,12

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Altasciences Preclinical Approaches to GLP-1 RA Development Preclinical studies for first generation GLP-1 RA therapeutics for treatment of diabetes have generally been standard GLP studies, conducted with normal-weight animal models

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