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Mechanistic insights into GLP-1 receptor agonists and reward pathways

However, excessive length may impede ligand to bind and activate receptor

Pharmacological characterization To examine whether the potent weight loss observed in vivo after GLP-1MK-801 treatment is attributable to pharmacological synergy between GLP-1 and MK-801 or consequential to altered pharmacokinetic properties of the parent GLP-1 analogue, we designed and synthesized a conjugate comprising an inactive MK-801 surrogate 22 (Supplementary Fig

doi: 10.1111/dom.13137 34 TrujilloJMNufferWSmithBA

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