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Roughly 65,000 participants had used melatonin for at least a year and formed the melatonin group. Another 65,000 who had never been prescribed melatonin served as a matched control group, adjusted across 40 factors including age, sex, body mass index, race, blood pressure, and medications for heart and nervous system diseases

To make it even worse, less efficient mitochondria produce less energy which means cells have a harder time carrying out bodily processes and it becomes a downward spiral of inflammatory conditions

Medications like semaglutide and tirzepatide mimic natural hormones that regulate appetite and digestion

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The Antibiotic Elimination Effect : When the investigators cleared the mices gut microbiomes using broad-spectrum antibiotics, the antidepressant effects of liraglutide completely vanished