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Sanyal AJ, Campbell-Sargent C, Mirshahi F, Rizzo WB, Contos MJ, Sterling RK, Luketic VA, Shiffman ML, Clore JN (2001) Nonalcoholic steatohepatitis: association of insulin resistance and mitochondrial abnormalities

Doing so could lead to increased stomach acid production and worsening symptoms

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This is why vial size alone doesnt dictate a fixed water volume