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In certain conditions, this effect is considered beneficial as it can impede tumor growth, delay disease progression, and even lead to the elimination of some cancer cells through the induction of an immune response [55]

Chronic illness, inadequate nutrition, alcohol use, smoking, and prolonged stress may also reduce levels

Intravenous, intramuscular, and nebulized routes achieve higher systemic levels but require clinical administration and are reserved for specific medical indications

It is obvious that identifying an oxidative modification and the targeted cysteine is insufficient and case-by-case studies have to be performed to decipher the impact on enzyme activity

Therefore, proper diet and supplementation are needed to boost glutathione levels in pregnancy