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These tissue samples were confirmed by histopathological examination, and before use, informed consent of the patient was obtained as authorized with the Ethics Committee of Tianjin Central Obstetrics and Gynecology Hospital
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Despite this, a substantial body of pre-clinical and limited clinical research has mapped DSIPs pharmacological effects across multiple systems, identifying several probable mechanistic axes including NMDA receptor modulation, adrenergic system regulation, MAPK/ERK cascade interaction, and mitochondrial respiration effects while acknowledging that the existence of an undiscovered DSIP-like endogenous peptide(s) may account for part of the DSIP-like immunoreactivity observed in tissue distribution studies