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Red, blue and black colourations are particularly serious signs

Strategy 15: consider temporary dose reduction If fatigue significantly impairs your quality of life and does not respond to the strategies above, discuss a temporary dose reduction with your healthcare provider

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Certainty of evidence All primary and secondary outcomes were judged to have high certainty of evidence across all GRADE approach [11] domains, including risk of bias (D1), inconsistency (D2), indirectness (D3), imprecision (D4), publication bias (D5)

In line with new online pharmacy regulations issued by the General Pharmaceutical Council (GPhC), many pharmacies must now verify additional health information before prescribing weight loss medication