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In addition, transgenic mice with whole-body MC4R deficiency exhibit impaired upregulation of BAT UCP1 in response to cold exposure when compared to wild-type controls [40]

The US FDA approved it on January 6, 2023, through an accelerated approval pathway on the basis of evidence of amyloid removal in a phase 2 trial (NCT01767311) and because it had a likelihood of having clinical benefits [41] A double-blind, placebo-controlled phase 2 trial recruited 856 patients with AD with mild cognitive impairment (MCI) or mild dementia and verified amyloid pathology through amyloid PET or CSF A1-42 [42]