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K., Aktas, A., et al

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Melatonin is a hormone produced by the pineal gland

It is indicated for the treatment of adult patients with the following conditions: Metastatic colorectal cancer who have received prior treatment with fluoropyrimidine-, oxaliplatin- and irinotecan-based chemotherapy, an anti-VEGF biological therapy, and if they have RAS wild-type, an anti-EGFR therapy

Human studies are less conclusive but still concerning