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Individuals with a BMI of 3034.9 kg/m (or 27.532.4 kg/m for the specified ethnic groups) may be considered if they have at least one weight-related comorbidity

The question then becomes not whether to replace Metformin entirely, but whether newer medications might reduce or eliminate the need for multiple additional medications that were historically required

Being on a low or early-stage dose, or hitting a metabolic plateau after long-term use, can slow or pause weight changes

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