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286 Besides, -catenin responsive transcription (CRT) is another crucial therapeutic target in combating various cancers and CRT-inhibitory drugs (iCRT3, iCRT5, iCRT14) are specifically cytotoxic to human colon cancer cells and enhance the infiltration of T and NK cells in syngeneic mouse models of CRC by blocking -catenin/TCF interaction

Intermittent fasting from dawn to sunset for 4 weeks is associated with an anticancer serum proteomic signature This pilot study has important clinical implications, specifically from the standpoint of type of intermittent fasting on cancer prevention in subjects with metabolic syndrome