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The liver processes toxins, heavy metals, metabolic waste, and pharmaceutical drugs through two primary phases

Abbreviations AD Alzheimers disease AEDs antiepileptic drugs ARE antioxidant response elements CNS central nervous system Cys cysteine SLC7A11 cystine/glutamate antiporter solute carrier family 7 member 11 CoQ10 coenzyme Q10 DFO deferoxamine DCYTB duodenal cytochrome B reductase FSP1 ferroptosis suppressor protein 1 FeCl 3 ferric chloride DMT1 divalent metal transporter 1 GSH glutathione GSR glutathione reductase GPX4 glutathione peroxidase 4 Glu glutamate Gly glycine HCP-1 heme carrier protein-1 HO-1 heme oxygenase 1 OH hydroxyl radical H 2 O 2 hydrogen peroxide HS hippocampus sclerosis IREB2 iron-responsive element-binding protein 2 KA kainic acid Keap1 Kelch-like ECH-associated protein 1 MTLE mesial temporal lobe epilepsy Nrf2 nuclear factor erythroid 2 related factor 2 NCOA4 nuclear receptor co-activator 4 PD Parkinsons disease PTE post-traumatic epilepsy ROS reactive oxygen species RNS reactive nitrogen species TBI traumatic brain injury O 2 superoxide anion STEAP3 six-transmembrane epithelial antigen of prostate 3 SIRT3 Sirtuin3 SAH subarachnoid hemorrhage TLE temporal lobe epilepsy TF transferrin TFR1 transferrin receptor-1

Ladd et al