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Medicines with a narrow therapeutic index where small changes in blood concentration can have significant clinical consequences merit particular attention

Additionally, a discrepancy has been noted concerning the distribution of persistent organic pollutants (POPs) between mother and newborn, linked to metabolic capabilities and resulting in underestimation of fetus exposure to these pollutants [128,129]

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Excessive Alcohol Intake Alcohol potentiates the effect of metformin on lactate metabolism and this may increase the risk of metformin-associated lactic acidosis