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Vance et al., 2022)

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[ 8 ] In humans, one study found that DSIP reduced circulating ACTH levels, while another found no effect on CRH-stimulated ACTH and cortisol secretion

The simultaneous activation of GIP and GLP-1 receptors may have central synergistic effects on appetite control, greater than selective GLP-1 receptor agonists [55], although preliminary studies do not support this hypothesis [56]

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