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Specific defensive mechanisms may be triggered by tissue damage resulting from ROS production

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Once training began, both groups gained about 2 kilograms (4.4 pounds) of lean body mass over 12 weeks, but creatine users did not gain more than those who did not take it, indicating the supplement gave an early bump in lean body mass but did not enhance long-term gains from resistance training

doi: 10.1172/jci.insight.163030 48 BowmanSJFoxRDornerTMarietteXPapasAGrader-BeckTet al

But if it does not work for you, then there is another option try it with a small amount of healthy fat, such as some slices of avocado or a handful of nuts