can tirzepatide cause kidney problems vs. Semaglutide: What You Should Know 18 Possible Side Effects of

Acknowledgements This work was supported by National Natural Science Foundation of China (82388201 and 82350111), National Key Research and Development Program of China (2022YFA1206000), Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences (2021-I2M-1-021 and 2023-I2M-2-005), Noncommunicable Chronic Diseases National Science and Technology Major Project (2025ZD0552500), China Postdoctoral Science Foundation (2024M750249 and 2025T180405) and Haihe Laboratory of Cell Ecosystem Innovation Fund (22HHXBSS00009)

Oolong Tea Extract and Citrus Peel Polymethoxyflavones Reduce Transformation of L-Carnitine to Trimethylamine-N-Oxide and Decrease Vascular Inflammation in L-Carnitine Feeding Mice

The company developed tirzepatide, Zepbound's active ingredient, as a novel dual receptor agonist targeting both GIP and GLP-1 pathways

(Cu: OR = 1.183, p = 0.025

glucose, polyamine, cell-wall, and energy metabolism