Statements Author contributions Methodology: AP and AB
However, outliers were analyzed for these correlations using the interquartile range (IQR) method
These could include other classes of diabetes medications, different weight loss strategies, or more frequent monitoring if GLP-1 drugs are deemed necessary
1 Introduction Osteoarthritis (OA) is among the most prevalent degenerative joint diseases globally, affecting more than 500 million people worldwide and ranking as the leading cause of disability among adults aged 50 years and older ( Ferroptosis, first reported in 2012, is a novel form of cell death distinct from classical apoptosis, pyroptosis, and necrosis ( Due to the possible critical role of ferroptosis in OA, there has been a surge of interest in elucidating its molecular mechanisms and exploring potential therapeutic strategies
These findings informed the creation of a unique formulation first validated through an in-vitro cell culture study, which confirmed its ability to activate GLP-1 pathways, reduce the enzyme responsible for breaking it down, and increase receptor activation