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Mechanistically, the binding of BPC157 to FBXO22 induces steric hindrance that suppresses FBXO22-mediated ubiquitination and degradation of its substrate BACH1

The litigation forced the agency to backtrack, and the FDA late last year agreed to convene two public meetings of outside advisers to review several peptides flagged for safety risks

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Other peptides under investigation Several additional peptides are being studied for disc-related applications, though with less established evidence: Vasoactive Intestinal Peptide (VIP) has demonstrated the ability to slow disc degeneration progression and improve aggrecan levels in mouse studies

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