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Emerging evidence further indicates that MTs particularly MT1 and MT2A constitute a critical cytoplasmic defense layer against cuproptosis by acting as effective copper sponges that sequester excess Cu + and restrict its aberrant interaction with mitochondrial targets 170,173,174

To develop liver fibrosis, rats in Group 2, the TAA group, received IP injections of TAA (100 mg/kg b.wt), twice weekly for 6 weeks ( 2.4 Preparation of blood and liver tissues Twenty-four hours after the last injection, blood was obtained from the tail vein under anesthesia with intraperitoneal injections of ketamine (50 mg/kg) + xylazine (25 mg/kg) dissolved in saline

Ferrostatin-1 is able to increase survival of UV-B-treated human lens epithelial cells and decreases the opaque region in UV-B irradiated mouse lenses [128] linking lens damage to ferroptosis

doi: 10.1093/ije/dyw192