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Tirzepatide is FDA-approved (for diabetes and weight loss, depending on the brand) and works as a dual-agonist, targeting GLP-1 and GIP receptors to reduce appetite, improve insulin response, and support weight loss

Patients using naltrexone for opioid use disorder face an additional consideration: GLP-1 medications can delay gastric emptying, potentially reducing absorption of oral naltrexone if taken simultaneously

Those consuming the probiotic lost more weight than those taking a placebo

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They will oversee the conduct of the trial at any unexpected time and will issue recommendations for early termination, modifications, or continuation of the trial, if necessary