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Because digestion slows down, some people experience: Nausea Constipation Feeling overly full Reduced appetite Bloating Occasional acid reflux These symptoms are usually temporary and often improve as your body adjusts

Skipping meals entirely or going extended periods without eating can lead to blood glucose fluctuations, particularly concerning for individuals with diabetes

Managing Expectations & Practical Guidance for Patients As orforglipron moves toward approval and commercial availability, patients, providers, and the broader public will need realistic expectations about what this drug can and cannot do

Do not self-administer without any training or instructions from a doctor or a nurse