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These effects were not reproduced in 3-AR knockout mice, suggesting that the 3-AR plays a key role in the compounds chronic metabolic effects (Heffernan et al

Br J Pharmacol (2013) 168:193345

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D27 is described as an iron-containing enzyme in the chloroplast that participates in the isomerization of carotenoids, including the conversion of all-trans--carotene to 9-cis--carotene, which is essential for subsequent CCD7 and CCD8 mediated reactions in SL biosynthesis 156

Nonetheless, abdominal pain after cholecystectomy has multiple potential causes, so any new or severe discomfort warrants prompt medical evaluation