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It has been demonstrated that a subset of a so-called atypical Spitz tumors is characterized genetically by the presence of BAP1 and BRAF V600E mutation occurring in either familial or sporadic setting, the former being associated with development of diverse malignancies, thus representing a cutaneous marker of a cancer syndrome (see corresponding section)

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This study aims to review the latest research progress in the application of GLP-1RAs in the management of sarcopenia, analyze its key molecular pathways, and explore its role in insulin resistance, mitochondrial function, inflammation, protein metabolism balance, autophagy, and the activation of related signaling pathways