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As approved indications continue to broaden, and adoption scales in those with established disease, the cumulative impact on public health could be profound

In its recent evaluation, the EFSA Panel on contaminants took note of the very low levels of the principle OTA adduct in rat kidney (reported range 2070 10 9 nucleotides) and stated: It remains unclear whether and to what extent these DNA adducts are formed in vivo and which metabolic pathway(s) are responsible for the formation (EFSA 2020)

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These findings suggest that further investigation into the mechanisms by which IL-6 influences ALD is necessary