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The second, third, and fourth group received an oral dose of Sildenafil (1.48 mg/kg), Tadalafil (0.285 mg/kg), and Vardenafil (0.285 mg/kg) respectively, three times per week for 12 weeks

Metformin commonly causes gastrointestinal upset, including nausea and diarrhea, particularly when first starting

While lifestyle interventions remain the cornerstone of treatment, many patients struggle to achieve or maintain meaningful weight reduction

Even that small a percentage point is significant, however, and the industry is right to be keeping an eye on it