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Introduction Clinical features Causes Investigations Treatment A melanotic macule is a well-defined, oval, brown to black, flat patch usually found on the central third of the lower lip, however it can more rarely occur on the penis or vulva

The efficacy of these treatments, ranked in order of mean RD, was as follows: RH, transcranial direct current stimulation, NBO, imatinib, uric acid, nelonemdaz, butylphthalide, cerebrolysin, ApTOLL, nerinetide, theophylline, remote ischemic conditioning, otaplimastat, simvastatin and albumin

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For oral formulations, the gastrointestinal side effects are more pronounced

A., Korma, S