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For instance, in mouse embryonic stem cells, targeted disruption of glucose-6-phosphate dehydrogenase, which is the rate-limiting enzyme in the pentose phosphate pathway, the predominant metabolic pathway for the generation of NADPH (a cofactor of GR), renders cells extremely sensitive to H 2 O 2 -induced cell death 34

Having a baseline measurement allows the prescribing team to monitor for clinically significant changes over time and adjust the protection plan accordingly

In addition, three important antioxidant enzymes, GST, SOD, and ascorbate peroxidase (APX), displayed significantly higher activities in transgenic lines after inoculation with F

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