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The modularity of ROSALIND has permitted the development of transcriptional circuits controlled not only by metallosensors, including SmtB (Zn II ), CsoR (Cu/Zn II ) and CadC (Pb II /Cd II ), but also those capable of detecting small organic molecules, such as TetR (tetracycline), MphR (erythromycin) and QacR (benzalkonium chloride)

Next we investigated viral uptake by pre-binding HPV16 to cells followed by a 2h shift to 37C to allow entry

Fur The ubiquitous Fur family proteins have evolved to sense all first-row, late d -block divalent metal ions with the exception of Cu II , and one specific reactive oxygen species, hydrogen peroxide (Figure 14A)

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Nature 601 , 252256 (2022)