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Examples of drugs that exhibit flow dependent hepatic clearance (high hepatic extraction ratio) include: Morphine , Lidocaine, Verapamil, Nitroglycerin, Propranalol Flow-Dependent Clearance The clearance of high-extraction drugs is primarily dependent on hepatic blood flow

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Mutations in both proB and proA , the first two genes in L-proline biosynthesis, provided a new pathway for -glutamyl cysteine formation via the selective interception of ProB-bound -glutamyl phosphate by amino acid thiols, likely through an S-to-N acyl shift mechanism

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