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It also modulates inflammatory signaling, reducing excessive inflammation that can impair healing while maintaining the beneficial inflammatory signals needed to recruit stem cells and initiate repair

Independent replication , because a single positive trial even a good one is a beginning, not a conclusion

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Why they matter: Large randomised cardiovascular and renal outcome trials (EMPA-REG OUTCOME, DAPA-HF, DAPA-CKD, EMPEROR-Reduced/Preserved, CREDENCE, EMPA-KIDNEY) consistently showed reductions in heart-failure hospitalisation, progression of chronic kidney disease, and cardiovascular death