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Known favorable interactions observed in the docking pose of the query molecule can be emphasized in the ROCS search strategy to identify chemically similar molecules derived from a different scaffold

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As traditional treatments for T2DM have focused on pancreatic -cell dysfunction and insulin resistance, it is additionally recognized that hyper-glucagonemia in pancreatic -cells with elevation of glucose absorption in the kidney (4) and tissue inflammation (5) are also associated with T2DM

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