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I am not aware of any berberine trial comparable to LEADER or SELECT: large, multicenter, multi-year, and designed to test cardiovascular or mortality outcomes

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doi: 10.1016/J.BIOPHA.2020.111156 160 NatarajanR.PechenyakB.VyasU.RanganathanP.WeinbergA.LiangP.et al (2014)

Milk Thistle and Fungal Infections An in vitro study from 2016 showed that silibinin can induce cell death in the yeast fungus Candida albicans, suggesting antifungal properties