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doi: 10.1038/aps.2016.21 Summary Keywords metformin, intestinal microbiota, gastrointestinal mucosal barrier, SCFAs, bile acid metabolism Citation Wang Y, Jia X and Cong B (2024) Advances in the mechanism of metformin with wide-ranging effects on regulation of the intestinal microbiota

Accountability through regular weigh-ins, whether self-directed or professionally supervised, helps maintain focus and allows early intervention when weight trends upward

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Common complaints Several reviewers note that vials sometimes appear to contain slightly less medication than expected, with the final weekly dose feeling short

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