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Since alcohol, especially when consumed chronically, augments the toxic potential of acetaminophen, many people unknowingly put themselves at risk of significant liver damage by consuming acetaminophen and alcohol together (Sharma 2009

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Consider gastroprotection if you have risk factors for NSAID-related complications, including: age 65 or over, history of peptic ulcer or GI bleeding, high-dose NSAID use, concomitant use of anticoagulants/antiplatelets/SSRIs, or significant comorbidities